# Experiments and overview

> Reading list | Eterna Telehealth — The Eterna Telehealth reading list: Epitalon cell cultures, melatonin synthesis, mouse survival, Epithalamin follow-up and a broader review.

**Reading room**

The experiments and review discussed in this collection.

## An entry point

The [Epitalon review](https://pubmed.ncbi.nlm.nih.gov/40141333/) ranges across proposed mechanisms and acknowledges limited physical and structural characterisation. I appreciate that admission. It gives the smaller experiments room to remain questions.

The list below includes the studies cited throughout Eterna Telehealth. The essay on [human follow-up](/human-follow-up) concerns Epithalamin, as the study itself does.

## Experiments by subject

For cell work, start with [telomerase-negative human fibroblasts](https://pubmed.ncbi.nlm.nih.gov/12937682/), then [the normal and breast-cancer cell lines](https://pubmed.ncbi.nlm.nih.gov/40908429/). The [rat pinealocyte culture study](https://pubmed.ncbi.nlm.nih.gov/22816096/) concerns melatonin synthesis.

For whole-animal observations, there are [female Swiss-derived SHR mice](https://pubmed.ncbi.nlm.nih.gov/14501183/) and [a rat model of chemically induced colon carcinogenesis](https://pubmed.ncbi.nlm.nih.gov/12049808/). The [elderly human cohort](https://pubmed.ncbi.nlm.nih.gov/14523363/) brings a different preparation and an observational comparison.

## References

[1] Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells https://pubmed.ncbi.nlm.nih.gov/12937682/
[2] Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity https://pubmed.ncbi.nlm.nih.gov/40908429/
[3] Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture https://pubmed.ncbi.nlm.nih.gov/22816096/
[4] Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice https://pubmed.ncbi.nlm.nih.gov/14501183/
[5] Peptides of pineal gland and thymus prolong human life https://pubmed.ncbi.nlm.nih.gov/14523363/
[6] Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats https://pubmed.ncbi.nlm.nih.gov/12049808/
[7] Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties https://pubmed.ncbi.nlm.nih.gov/40141333/

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Eterna Telehealth gives my fascination with biological time a home in published research, as an editorial site that operates no healthcare business and gives no medical advice.